Tyaunna Marshall led the Yellow Jackets with 23 points on the night, but despite Marshall's output and eight points and eight rebounds from Dawnn Maye, the Yellow Jackets couldn't keep pace with No. 4 Duke.
Duke got out to an early lead behind Williams and Tricia Liston, who finished with 13 points and five rebounds.
Georgia Tech's Aaliyah Whiteside pulled the Yellow Jackets to within 12 points to open the second half, but Georgia Tech never got much closer than that, as Duke's Haley Peters' 11 rebounds and 11 points helped seal the win for the Blue Devils. Whiteside finished with six points and eight rebounds.
Duke was also helped by big production off the bench, as Ka'lia Johnson, Chloe Wells and Sierra Moore combined for 19 bench points to Georgia Tech's seven off the bench.